Tri and tetrasubstituted alkenes are often the starting point, but how to get them

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By Sander Kluwer Alkenes, and particularly substituted alkenes form an important class of compounds are commonly part of biologically active molecules or form the substrate for numerous catalytic conversions such as hydroformylation and (asymmetric) hydrogenation. The synthetic efforts increase with the number of substituents present on the C=C double bond as the possible arrangements increases […]

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Cobalt hydroformylation – The old kid on the block, catching up running

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InCatT blog

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A direct method for carboformylation at last: the acid chloride does the job!

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Aldehydes occupy an important place within the landscape of fine chemicals, notably due to their extensive use in a wide variety of products such as detergents, fragrances, insecticides, etc. The most straightforward type of reactions to produce aldehydes in an atom-efficient manner and direct way lies in the carboformylation of unsaturated compound. Among them, hydroformylation […]

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Site-selective cross coupling by fine-tuning the supramolecular interaction (an article review)

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The demand for molecules of increasing complexity creates a strong need for new chemical tools. In particular, the synthesis of polyarene molecules bearing multiple substituents is challenging as no direct methods allow for the selectively introduction of non-identical substituents. In this respect, chemoselective reactions play a crucial role as they represent a straightforward method, suppressing […]

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Switching the acid, one palladium catalyst swaps between alkyne hydroformylation or semihydrogenation (an article review)

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In drug discovery, chemodivergent reactions have recently attracted great interest because of their involvement in the synthesis of libraries of small molecules. The concept of diversity-oriented synthesis relates to the selective formation of various well-defined products from only one readily available starting material. This can be achieved by steering the reaction’s selectivity through fine-tuning of […]

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Scientists make supramolecular iridium catalyst with enzyme-like precise conversions

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By Sander Kluwer, InCatT B.V. The conversion of feedstocks to useable chemical compounds is at the heart of chemistry and the chemical industry. Many catalytic transformations have been developed in the last decades to mature processes. Despite numerous efforts, there were always a number transformations that remained a tough nut to crack. One such conversion […]

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InCatT’s scale up studies using DoE and kinetics – a powerful combination

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The scale up of a reaction from gram to multi-kilogram scale is not always straightforward and requires crucial knowledge about the reaction. One way of upscaling is to perform One Factor At a Time (OFAT) but this only provides very limited information about the reaction space. More appropriate is the statistical DoE (design of experiment) […]

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Robust Highly-Dispersed Heterogeneous Ruthenium Catalysts – Just Add a Pinch of Sodium (article review)

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The importance of heterogeneous catalytic hydrogenation reactions cannot be overemphasized and is one of the backbones of the chemical industry. Highly active and robust catalysts remain an objective particularly from an economical point of view. Catalyst deactivation, the loss over time of catalytic activity and/or selectivity, is a problem of great and continuing concern in […]

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Solved at last: Direct catalytic synthesis of chiral hydroxylamines from oximes (an article review)

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The increasing need for structural diversity in the design of bioactive molecules results in the steady appearance of new synthetic challenges. Consequently, the industry regularly faces new synthetic problems that requires the development of innovative approaches. Of particular concern is the synthesis of chiral compounds for the production of agrochemicals and pharmaceuticals. Also, the synthesis […]

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Selective hydroformylation by remote control

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A joined research paper by InCatT and the University of Amsterdam has recently published as HOT PAPER in Chemistry European Journal describing the selective hydroformylation by remote supramolecular control. Yes, also fatty acids! Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control by Pim R. Linnebank, Stephan Falcão Ferreira, Alexander M. Kluwer, Prof. Dr. […]

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