Amine-BF3 salts do the trick. How to introduce tertiary amine in late-stage functionalization?

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How to introduce tertiary amine in late-stage functionalization

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Can Palladium do what the Rhodium-workhorse cannot do? A case of scalable Isoselective hydroformylation

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By: Valentinos Mouarrawis and Sander Kluwer The importance of hydroformylation cannot be overstated! This chemical reaction entails the addition of syngas, a mixture of carbon monoxide (CO) and hydrogen (H2), to olefins in the presence of a catalyst to produce aldehydes. Since its discovery by Otto Roelen in 1938, the hydroformylation process has evolved into […]

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Palladium and Nickel Catalysts in Industry: Opportunities and Challenges.

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By Valentinos Mouarrawis & Sander Kluwer InCatT B.V. Transition metal catalysis occupies a pivotal role in the modernization of our chemical industry because it ensures more efficient use of scarce natural resources and also aids in the minimization of waste production. Besides these economic reasons, the development of efficient catalytic processes is of crucial importance […]

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Tri and tetrasubstituted alkenes are often the starting point, but how to get them

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By Sander Kluwer Alkenes, and particularly substituted alkenes form an important class of compounds are commonly part of biologically active molecules or form the substrate for numerous catalytic conversions such as hydroformylation and (asymmetric) hydrogenation. The synthetic efforts increase with the number of substituents present on the C=C double bond as the possible arrangements increases […]

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Cobalt hydroformylation – The old kid on the block, catching up running

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InCatT blog

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A direct method for carboformylation at last: the acid chloride does the job!

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Aldehydes occupy an important place within the landscape of fine chemicals, notably due to their extensive use in a wide variety of products such as detergents, fragrances, insecticides, etc. The most straightforward type of reactions to produce aldehydes in an atom-efficient manner and direct way lies in the carboformylation of unsaturated compound. Among them, hydroformylation […]

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Site-selective cross coupling by fine-tuning the supramolecular interaction (an article review)

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The demand for molecules of increasing complexity creates a strong need for new chemical tools. In particular, the synthesis of polyarene molecules bearing multiple substituents is challenging as no direct methods allow for the selectively introduction of non-identical substituents. In this respect, chemoselective reactions play a crucial role as they represent a straightforward method, suppressing […]

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Switching the acid, one palladium catalyst swaps between alkyne hydroformylation or semihydrogenation (an article review)

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In drug discovery, chemodivergent reactions have recently attracted great interest because of their involvement in the synthesis of libraries of small molecules. The concept of diversity-oriented synthesis relates to the selective formation of various well-defined products from only one readily available starting material. This can be achieved by steering the reaction’s selectivity through fine-tuning of […]

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Scientists make supramolecular iridium catalyst with enzyme-like precise conversions

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By Sander Kluwer, InCatT B.V. The conversion of feedstocks to useable chemical compounds is at the heart of chemistry and the chemical industry. Many catalytic transformations have been developed in the last decades to mature processes. Despite numerous efforts, there were always a number transformations that remained a tough nut to crack. One such conversion […]

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InCatT’s scale up studies using DoE and kinetics – a powerful combination

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The scale up of a reaction from gram to multi-kilogram scale is not always straightforward and requires crucial knowledge about the reaction. One way of upscaling is to perform One Factor At a Time (OFAT) but this only provides very limited information about the reaction space. More appropriate is the statistical DoE (design of experiment) […]

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