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By Sander Kluwer Enantioselective hydroboration of C=C double bonds is a pivotal reaction in organic synthesis, enabling the synthesis of chiral organoboron compounds with high precision. This process involves the addition of borane to alkenes, favoring the formation of one enantiomer over the other. Historically, significant advancements have been made with mono-, di-, and trisubstituted […]
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The importance of this research area is highlighted by three high-profile papers that appeared over the course of 2022.
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By Valentinos Mouarrawis and Sander Kluwer Catalysis is key for modernizing the chemical industry by making more efficient use of resources and minimizing waste production. The development of efficient catalytic processes is of crucial importance for sustainable-oriented applications, positioning catalysis at the heart of our quality of life. In the fine chemical industry, complex transformations […]
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InCatT Blog – new technology to obtain chiral hydroxylamines
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The olefin metathesis reaction is a powerful and widely used catalytic tool to form carbon–carbon double bond. The increasing interest in this reaction in drug discovery and process chemistry is evidenced by the number of commercial applications used at manufacturing scale. Currently, the most applicable catalysts for this transformation are based on ruthenium–carbene complexes. However, […]
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How to introduce tertiary amine in late-stage functionalization
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By: Valentinos Mouarrawis and Sander Kluwer The importance of hydroformylation cannot be overstated! This chemical reaction entails the addition of syngas, a mixture of carbon monoxide (CO) and hydrogen (H2), to olefins in the presence of a catalyst to produce aldehydes. Since its discovery by Otto Roelen in 1938, the hydroformylation process has evolved into […]
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By Valentinos Mouarrawis & Sander Kluwer InCatT B.V. Transition metal catalysis occupies a pivotal role in the modernization of our chemical industry because it ensures more efficient use of scarce natural resources and also aids in the minimization of waste production. Besides these economic reasons, the development of efficient catalytic processes is of crucial importance […]
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By Sander Kluwer Alkenes, and particularly substituted alkenes form an important class of compounds are commonly part of biologically active molecules or form the substrate for numerous catalytic conversions such as hydroformylation and (asymmetric) hydrogenation. The synthetic efforts increase with the number of substituents present on the C=C double bond as the possible arrangements increases […]
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