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By Sander Kluwer, InCatT B.V. The conversion of feedstocks to useable chemical compounds is at the heart of chemistry and the chemical industry. Many catalytic transformations have been developed in the last decades to mature processes. Despite numerous efforts, there were always a number transformations that remained a tough nut to crack. One such conversion […]
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The scale up of a reaction from gram to multi-kilogram scale is not always straightforward and requires crucial knowledge about the reaction. One way of upscaling is to perform One Factor At a Time (OFAT) but this only provides very limited information about the reaction space. More appropriate is the statistical DoE (design of experiment) […]
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The importance of heterogeneous catalytic hydrogenation reactions cannot be overemphasized and is one of the backbones of the chemical industry. Highly active and robust catalysts remain an objective particularly from an economical point of view. Catalyst deactivation, the loss over time of catalytic activity and/or selectivity, is a problem of great and continuing concern in […]
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The increasing need for structural diversity in the design of bioactive molecules results in the steady appearance of new synthetic challenges. Consequently, the industry regularly faces new synthetic problems that requires the development of innovative approaches. Of particular concern is the synthesis of chiral compounds for the production of agrochemicals and pharmaceuticals. Also, the synthesis […]
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A joined research paper by InCatT and the University of Amsterdam has recently published as HOT PAPER in Chemistry European Journal describing the selective hydroformylation by remote supramolecular control. Yes, also fatty acids! Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control by Pim R. Linnebank, Stephan Falcão Ferreira, Alexander M. Kluwer, Prof. Dr. […]
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The testing of libraries of phosphorus ligands is at the core of catalyst screening for the optimization of industrially relevant process. Among these processes, hydrogenation, hydroformylation and cross coupling reactions strongly depends on such methodology. In this regard, the availability of structurally and electronically diverse phosphorus ligands is essential to fully explore the relationship between […]
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Dear customers and partners, The outbreak of the COVID-19 virus has changed the world around us drastically and it has affected all of us in our working and daily life. Restrictions have been imposed by the government and for many companies the activities are reduced. This undoubtedly results in that many projects and programs fall […]
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