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Bulky Alkenes Converted: New Hydroboration Technology
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By Sander Kluwer Enantioselective hydroboration of C=C double bonds is a pivotal reaction in organic synthesis, enabling the synthesis of chiral organoboron compounds with high precision. This process involves the addition of borane to alkenes, favoring the formation of one enantiomer over the other. Historically, significant advancements have been made with mono-, di-, and trisubstituted […]
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Nickel solves a long-lasting challenge; An efficient asymmetric hydrogenation of oximes to produce chiral hydroxylamines
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InCatT Blog – new technology to obtain chiral hydroxylamines
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IRON does the job of Ruthenium! Iron-catalyzed ring-opening metathesis polymerization of olefins
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The olefin metathesis reaction is a powerful and widely used catalytic tool to form carbon–carbon double bond. The increasing interest in this reaction in drug discovery and process chemistry is evidenced by the number of commercial applications used at manufacturing scale. Currently, the most applicable catalysts for this transformation are based on ruthenium–carbene complexes. However, […]
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Amine-BF3 salts do the trick. How to introduce tertiary amine in late-stage functionalization?
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How to introduce tertiary amine in late-stage functionalization
Read MoreCan Palladium do what the Rhodium-workhorse cannot do? A case of scalable Isoselective hydroformylation
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By: Valentinos Mouarrawis and Sander Kluwer The importance of hydroformylation cannot be overstated! This chemical reaction entails the addition of syngas, a mixture of carbon monoxide (CO) and hydrogen (H2), to olefins in the presence of a catalyst to produce aldehydes. Since its discovery by Otto Roelen in 1938, the hydroformylation process has evolved into […]
Read MoreTri and tetrasubstituted alkenes are often the starting point, but how to get them
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By Sander Kluwer Alkenes, and particularly substituted alkenes form an important class of compounds are commonly part of biologically active molecules or form the substrate for numerous catalytic conversions such as hydroformylation and (asymmetric) hydrogenation. The synthetic efforts increase with the number of substituents present on the C=C double bond as the possible arrangements increases […]
Read MoreCobalt hydroformylation – The old kid on the block, catching up running
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InCatT blog
Read MoreA direct method for carboformylation at last: the acid chloride does the job!
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Aldehydes occupy an important place within the landscape of fine chemicals, notably due to their extensive use in a wide variety of products such as detergents, fragrances, insecticides, etc. The most straightforward type of reactions to produce aldehydes in an atom-efficient manner and direct way lies in the carboformylation of unsaturated compound. Among them, hydroformylation […]
Read MoreSite-selective cross coupling by fine-tuning the supramolecular interaction (an article review)
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The demand for molecules of increasing complexity creates a strong need for new chemical tools. In particular, the synthesis of polyarene molecules bearing multiple substituents is challenging as no direct methods allow for the selectively introduction of non-identical substituents. In this respect, chemoselective reactions play a crucial role as they represent a straightforward method, suppressing […]
Read MoreSwitching the acid, one palladium catalyst swaps between alkyne hydroformylation or semihydrogenation (an article review)
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In drug discovery, chemodivergent reactions have recently attracted great interest because of their involvement in the synthesis of libraries of small molecules. The concept of diversity-oriented synthesis relates to the selective formation of various well-defined products from only one readily available starting material. This can be achieved by steering the reaction’s selectivity through fine-tuning of […]
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